Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. causing a partial loss of gene function.

Etymologies

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Examples

  • Taken together, these two latter findings have challenged the concept that Wnt signalling in osteoblasts is a key pathway for the regulation of bone formation, which was further underscored by the finding that the osteopenia of rs/rs mice, carrying a hypomorphic mutation of the Wnt co-receptor Lrp6, is caused by increased bone resorption

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  • However, it did cause the formation of hypomorphic limbs as a result of increased cellular condensation and apoptosis.

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  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9.

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  • Pten hypomorphic and null allele; +/−, mice having a Pten wt and null allele.

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  • Pten hypomorphic and a wild-type (wt) allele; hy/−, mice having a

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  • Mouse embryos expressing the hypomorphic Notch1 [12f] allele, in combination with the inactive Notch1 [lbd]

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  • Mice homozygous for the hypomorphic Notch1 [12f] allele, which removes the single O-fucose glycan in epidermal growth factor-like repeat 12 (EGF12) of the Notch1 ligand binding domain (lbd), exhibit reduced growth after weaning and defective T cell development.

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  • Notch1 signaling in Notch1 [12f/lbd] compound heterozygous embryos is more defective than in compound heterozygotes expressing a hypomorphic Notch1 [12f]

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  • A mouse with exon 1 of the 6.1 Kb transcript gt resulted in hypomorphic expression of Dlc1 protein and an embryonic lethal phenotype in the homozygous condition, which indicates that this isoform plays a major role in mouse development.

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  • So reciprocally, it is possible that although hypomorphic mutations in Utp15p and Nhp2p, whose depletion results in early ribsome biogenesis defects, rather perturb downstream steps in the pathway.

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