- n. A particular topical immune-response modifier.
“A topical medicine called imiquimod is an immunomodulator.”
“Other common treatments include topical creams such as imiquimod, diclofenac, and fluorouracil.”
“Macrophages and NK1. 1+ cells were found to play an important role in the antitumor effects mediated by treatment with CRT/E7 DNA in combination with imiquimod.”
“Thus, our data suggests that the combination of therapeutic HPV DNA vaccination with topical treatment with the TLR7 agonist imiquimod enhances the antitumor immunity induced by DNA vaccination.”
“In addition, treatment with imiquimod led to increased number of NK1. 1+ cells and F4/80+ cells in the tumor microenvironment.”
“(CRT) linked to human papillomavirus type 16 (HPV-16) E7 antigen (CRT/E7) with the TLR7 agonist imiquimod for their ability to generate E7-specific immune responses and antitumor effects in tumor-bearing mice.”
“Furthermore, treatment with CRT/E7 DNA in combination with imiquimod leads to significantly improved antitumor effects and prolonged survival in treated mice.”
“We observed that treatment with CRT/E7 DNA in combination with imiquimod leads to an enhancement in the E7-specific CD8+ T cell immune responses and a decrease in the number of myeloid-derived suppressor cells in the tumor microenvironment of tumor-bearing mice.”
“FRIDAY, March 26 (HealthDay News) -- Zyclara topical cream (imiquimod 3. 75%) has been approved by the U.S.”
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