- adj. Of or pertaining to immunoregulation
“Ulcerative colitis (UC) is a chronic, relapsing disorder of unknown immunoregulatory dysfunction.”
“The SH2D1A gene produces a protein called SAP, which regulates how white blood cells combat infections such as Epstein-Barr virus (EBV) and controls how they produce antibodies and other immunoregulatory molecules.”
“Therefore, the difference in immune responses generated by the adoptive transfer of the DC subsets observed in our study is more likely reflecting a functional difference of the subsets in activating/modulating T cell responses rather than their difference in handling the microbes/antigens, especially considering the dramatic difference of the DC subsets in the expression of co-stimulatory molecules and the production of immunoregulatory cytokines.”
“Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection.”
“CD56 bright; this immunoregulatory subset produces a wide range of cytokines and chemokines after monokine stimulation, but its ability to kill target cells spontaneously is poor.”
“Since vitamin D is coming to be seen as an important immunoregulatory hormone, one has to wonder if this ancient population supplemented its diet with fish as a work around?”
“Previous studies have shown that people with MS have less of these immunoregulatory cells than people without MS which, coupled with the reduction in active lesions, supports further study of daclizumab.”
“Such immunoregulatory role is due to the IL-10 ability of inhibiting the expression of the most inducible cytokines and secondary mediators that contribute to inflammation.”
“Trillium has broad portfolio preclinical immunology programs, including two that target the CD200 immunoregulatory axis; a CD200-specific monoclonal antibody for the treatment of cancer, and a CD200Fc fusion protein for the treatment of autoimmune and inflammatory diseases.”
“Trillium's strong immunology foundation and its close connection to Toronto's world class immunology research community, has allowed it to build a suite of exciting biologies opportunities in the immunoregulatory field", added Dr. Michael Moore, Trillium's Chairman.”
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