Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A multi-protein complex that is responsible for inflammatory rheumatic diseases via activation of caspases

Etymologies

Sorry, no etymologies found.

Examples

  • Nlrp3 works by anchoring a large, multi-protein complex known as the Nlrp3 inflammasome where the messenger protein interleukin 18 (IL-18) is made.

    Medindia Health News

  • In this study, researchers showed IL-18 produced by the Nlrp3 inflammasome helped mice maintain healthy colon by triggering production of more epithelial cells to compensate for those damaged or destroyed by colitis.

    Medindia Health News

  • The missing link: how the inflammasome senses oxidative stress

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  • Influenza virus, a negative-stranded RNA virus that causes severe illness in humans and animals, stimulates the inflammasome through the Nod-like receptor NLRP3.

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  • Here we show that the influenza virus M2 protein, a proton-selective ion channel important in viral pathogenesis, stimulates the NLRP3 inflammasome pathway.

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  • Figure 5: M2 is sufficient to trigger signal 2 for inflammasome activation.

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  • However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown.

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  • Figure 1: Influenza viruses are specifically able to induce inflammasome activation.

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  • Figure 3: The M2 channel activity of influenza virus is required for inflammasome activation.

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  • This is the first time that the involvement of the inflammasome complexes was shown in MKD pathogenesis.

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