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“A quick online search clearly shows that exercise improves insulin-stimulated glucose uptake in type 2 diabetics and bone density and prevents ischemia/reperfusion injury in the heart.”
“There is no natural mechanism for killing excessive fat cells, because having massive pockets of insulin-stimulated adipocyte hyperplasia is not a natural condition.”
“Allick et al concluded that it was remarkable that, in the context of diabetes risk, 2 aspects of glucose homeostasis actually improved after consumption of the high-fat, low-carbohydrate diet: basal endogenous glucose production decreased, and insulin-stimulated nonoxidative glucose disposal increased.”
“Mean insulin-stimulated rates of glucose disappearance (ie, insulin sensitivity), after adjustment, increased from 0.01 mol kg1 min1/pmol L1 to 0.03 mol kg1 min1/pmol L1.”
“We found that Ang II completely blocks insulin-stimulated GLUT4 translocation and strongly inhibits insulin-mediated Akt phosphorylation on Ser”
“Inhibition of nitric oxide synthase and NAD (P) Hoxidase and scavenging of free radicals with myricetin restored insulin-stimulated Akt phosphorylation and GLUT4 translocation in the presence of Ang II.”
“Previous reports have shown that Ang II is able to modulate insulin-stimulated Akt activity and have suggested that this involves increased production of ROS”
“These compounds had no significant effect per se on GLUT4 translocation under control or insulin-stimulated conditions but abolished the effect of Ang II alone (data not shown).”
“Inhibition of MEK restores insulin-stimulated phosphorylation of Akt in the presence of Ang II”
“As shown in Effect of the MEK inhibitor U0126 on insulin-stimulated Akt phosphorylation.”
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