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- n. A system of gene capture and dissemination
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In the present study, we describe a new blaIMP-1-carrying integron that contains a new aminoglycoside resistance gene and its dissemination among genetically unrelated clinical isolates recovered from a Brazilian hospital.
This enzyme also promotes the random rearrangement of the resistance genes within the integron.
It is actually the antibiotics themselves that trigger the synthesis of the bacterial enzyme that captures the resistance genes and enables their expression in the integron.
The order of these genes in the integron determines the degree of priority for their expression: the first are expressed most highly and give the bacteria the corresponding resistance.
Schmidt AS, Bruun MS, Dalsgaard I, Larsen JL (2001) Incidence, distribution and spread of tetracycline resistance determinants and integron - associated antibiotic resistance genes among motile Aeromonads from a fish-farming environment.
Type 1 plasmids consisted of replicons F1A/F1B, blaTEM, IS26, and a class 1 integron with the genes dfrA12-orfF-aadA2-qacEDelta1-sulI.
Additionally, DNA sequencing of class 1 integron PCR amplicons from five example isolates identified antibiotic resistance gene cassettes (
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