Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- adjective Located between genes. Used of DNA sequences.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective genetics Describing the
noncoding sections ofnucleic acid betweengenes
Etymologies
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Examples
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Avp and Oxt genes that are separated by 4 kbp, the so-called intergenic region differences in gene expression were only restricted to the former.
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The downstream enhancer region, also referred to as the intergenic region between Avp and Oxt, contains three SNPs: A (+399) G with LABs carrying guanine and HABs adenine, T (+476) G with LABs carrying guanine and HABs thymine and C (+2444) A with LABs carrying adenine and HABs cytosine.
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Following a hunch, postdoctoral scholar Andrzej Wierzbicki decided to take a closer look at the stretches of DNA that lie between genes, the so-called intergenic regions.
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Furthermore, when they looked at where the mysterious transcripts are coming from, they are most frequently from regions of DNA near known genes, not just out of deep intergenic regions.
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In this essay, I review a 2007 study by Debrah Thompson and Roy Parker “Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae”, Mol.
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In this essay, I review a 2007 study by Debrah Thompson and Roy Parker “Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae”, Mol.
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Colours indicate either a 1.5-fold to 2.0-fold (blue) or a more than 2.0-fold (red) increase in the size of intronic (coloured boxes) or intergenic (coloured lines) regions, in comparison with the chicken reference.
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There clearly are still mysteries in there — they do identify a few novel transcripts that come up out of the intergenic regions — but they are small and rare, and the fact of their existence does not imply a functional role, since they could simply be byproducts of other processes.
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The correct relative sizes of predicted exons (black boxes), introns (white or coloured boxes) and intergenic regions (horizontal thick lines) permit direct comparisons (right).
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What was found in those enlarged intergenic regions is a greater invasion of degenerate DNA sequences: lots of additional retrotransposons, like LINES and SINES, which are all junk DNA.
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