American Heritage® Dictionary of the English Language, Fourth Edition
- n. Either of two proteins, released by macrophages and other cells, that induce the production of interleukin-2 by helper T cells and stimulate the inflammatory response.
- inter- + Greek leukos, white; see leuko- + -in. (American Heritage® Dictionary of the English Language, Fourth Edition)
“People with the rare, inherited condition, called cryoprin-associated periodic syndrome, or CAPS, have a genetic mutation that causes the body to overproduce a protein called interleukin-1 beta, which leads to inflammation and tissue damage.”
“The animals suffered an increase in an inflammation-causing chemical called interleukin-1, used by the body to fight infections, and had fewer complex nerve cells that carry signals to the brain from the rest of the body.”
“Aspirin blocks the pyrogen-induced production of prostaglandins, the central nervous system response to COX and the release of interleukin-1.”
“Novartis now aims to market Ilaris to treat gouty arthritis, also known as gout, a disease that is also triggered by overproduction of interleukin-1 beta.”
“The cytokines, including tumor necrosis factor alpha and interleukin-1, -4, -6, -8, and -10, result in a cascade of events that are highly destructive to lung tissue.”
“Carnitine can also decrease the production of pro-inflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor alpha.”
“That genetic mutation causes the body to overproduce interleukin-1, a protein tied to the immune system.”
“Novartis, meanwhile, is also testing Ilaris in juvenile rheumatoid arthritis, diabetes and respiratory disease, all of which it believes are caused in part by interleukin-1.”
“Dr. Hoffman of UCSD said interleukin-1 is probably tied to a host of inflammatory diseases, but unlike the situation with CAPS, it won't be the sole cause in other disorders.”
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