from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A lymphokine, released by helper T cells in response to an antigen or mitogen, that stimulates the growth of blood stem cells and lymphoid cells such as macrophages and mast cells.
Sorry, no etymologies found.
These depend on the presence of the growth factor interleukin-3 by combining them in microtissues with CHO cells (Chinese hamster ovary cells) that were engineered to secrete interleukin-3.
After proving that they could assemble cells into microtissues, Gartner and Bertozzi constructed a minute gland - analogous to a lymph node, for example - such that one cell type secreted interleukin-3 and thereby kept a second cell type alive.
CD123 is part of the interleukin-3 receptor, a protein that interacts with a growth factor (called a cytokine) that influences cell survival and proliferation.
Stemline's lead compound, SL-401, targets the interleukin-3 receptor which is expressed on multiple hematological cancers including leukemia blasts and leukemia cancer stem cells.
Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, et al. (2000) The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells.
3 Department of Chemistry, The Scripps Research Institute, San Diego, California, United States of America The SH2-containing-5′inositol phosphatase-1 (SHIP) influences signals downstream of cytokine / chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1 / CXCL-12 and interleukin-3.
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