Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An ionophore produced by the bacterium Streptomyces conglobatus, used in research relating to calcium in the body.

Etymologies

Sorry, no etymologies found.

Examples

  • For example, Dimebon treatment improved mitochondrial function and increased the number of surviving cells after treatment with a cell toxin known as ionomycin in a dose dependent fashion.

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  • Pen/Strep and 10% FCS, 0.5 µg/ml PMA, 0.5 µg/ml ionomycin for 3 h.

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  • Transcriptome analysis revealed that ten times more genes were differentially expressed after PMA/ionomycin stimulation than after LPS stimulation.

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  • Repression of MHC class I genes was observed after PMA/ionomycin stimulation despite an up-regulation of the gene cascade involved in peptide processing.

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  • The chip was used to study the immune response of pigs following stimulation of porcine peripheral blood mononuclear cells (PBMCs) with lipopolysaccharide (LPS) or a mixture of phorbol myristate acetate (PMA) and ionomycin for 24 hours.

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  • (F) Treatment with 25 µM MK-801 for 20 min prior to 5 µM ionomycin prevented ER fission and only caused minor effects on gross dendritic structure.

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  • (C) Normalized average FRAP signal over time in untreated neurons (blue) and the same neurons after ionomycin for an average of 35 min

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  • While such a result is typically interpreted as a general rise in cytosolic calcium is sufficient to trigger the phenomenon under study, secondary effects of ionomycin leading to NMDA receptor activation cannot be excluded.

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  • (B) Treatment with 5 µM ionomycin for 10 min caused ER fission along with a pronounced effect on gross dendritic structure (dendritic blebbing).

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  • The N-methyl, D-aspartate (NMDA) receptor antagonist MK-801 inhibited ER fission induced by glutamate as well as by ionomycin.

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