from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Either of two submicroscopic attachment points for chromosomal microtubules, present on each centromere during the process of cell division.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. the protein structure in eukaryotes which assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape
These complexes become attached to some of the spindle microtubules, which are then termed kinetochore microtubules.
We now believe that proteins in a structure called the kinetochore are among the most sensitive to degradation or mutation.
This force increases the efficiency with which chromosomes make bipolar spindle attachments and regulates kinetochore activities necessary for chromosome oscillation, but is not essential for chromosome congression.
Spindle fibers, composed of microtubules, have attached to the sister pairs of chromosomes at their point of attachment the kinetochore, or centromere.
During meiosis, fibres called microtubules attach themselves to the centre kinetochore of the chromosomes.
Overlaid onto these signals that promote orchestrated cell division are checkpoints that ensure appropriate mitotic spindle formation, a lack of DNA damage, kinetochore attachment, and that each daughter cell has the appropriate complement of DNA.
The kinetochore protein Mtw1 was epitope-tagged, allowing us to score the number of kinetochore foci in spread nuclei.
The initial study of centromere coupling reported that in chromosome spreads exhibiting centromere coupling, Zip1 foci and kinetochore pairs occur in approximately equal numbers (about sixteen) and exhibit a high level of co-localization
Chd1 mutant fly embryos does not interfere with centromere and kinetochore assembly, as the levels and localization of CenH3
The absence of most of kinetochore proteins is not surprising, as chromosomes should have sedimented during the extract clarification step.
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