- adj. pathology Of, pertaining to, or accompanied by lesions
“Early drafts of the Covenant contained the assumption that the socially unsane would naturally be hospitalized and readjusted, particularly since current psychiatry was quite competent to cure all non-lesional psychoses and cure or alleviate lesional psychoses, but Novak set his face against this.”
“In the initial release, whole-skin expression profiles from paired lesional/non-lesional samples of”
“Hegmans JP, Croughs P, Troost RJ, Prins JB, et al. (1997) The IL-1 system in psoriatic skin: IL-1 antagonist sphere of influence in lesional psoriatic epidermis.”
“Geneset Enrichment analysis (GSEA) independently confirmed a highly significant enrichment of those genes upregulated in psoriasis (defined as gene-set) in lesional skin of PPARβ/δ mice (figure 5c).”
“In order to independently confirm those results, we re-analyzed two publicly available large gene expression datasets, totalling 58 paired lesional and non-lesional skin samples, for the expression of all PPAR isotypes.”
“Upregulation of psoriasis-associated genes in lesional skin of PPARβ/δ transgenic mice.”
“FC = fold change lesional vs. non-lesional (psoriasis), or induced vs. non-induced (PPARβ/δ transgenic mice).”
“As shown in figure 5a, most of the top 50 genes upregulated in lesional skin of PPARβ/δ mice were found congruently upregulated in human psoriasis.”
“Representative immunohistochemistry of paraffin-embedded lesional (left) and control (middle) skin samples stained with anti-PPARβ/δ, as well as staining control (right).”
“Westergaard M, Henningsen J, Johansen C, Rasmussen S, Svendsen ML, et al. (2003) Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin.”
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