Examples
“Normally activated by near-starvation, SIRT-1 extends life by, among other things, reducing the amount of intracellular junk (called lipofuscin) that accumulates from metabolism.”
“5 Miscellaneous free-radical reactions form residues called lipofuscin or age pigment.”
“With age, there may be insufficient digestion of damaged macromolecules and organelles by the RPE, which will lead to progressive accumulation of biological "garbage", such as lipofuscin, and release of partially digested or undigested materials.”
“Superoxide free radicals, which is what these garbage molecules are called, combine with fatty acids to produce lipofuscin, which is an unstable, repulsive gunk that clogs up a cell like grease clogs a drain.”
“She was convinced that some substance such as lipofuscin must be responsible.”
““His lipofuscin accumulation rate started an exponential rise in sample two thousand one hundred forty-one, taken at the seventy-first hour,” Charlie said.”
“At the molecular level the buildup of lipofuscin is responsible for the loss of internal circulation that leads to cellular morbidity.”
“It is difficult to know how much lipofuscin was present in the initial donated bone marrow.”
“It is clear from our data that culturing hMSCs at 20% oxygen can lead to dramatic lipofuscin accumulation, while growth at 5% oxygen provides some protection.”
“To our knowledge, this work represents the first application of MPM in which long term monitoring of hMSC differentiation reveals quantitative changes in cellular metabolic activity (via computed redox ratio) and oxidative stress (via lipofuscin) using entirely endogenous sources of contrast.”
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