“Although dysfunction in the lymphatic system contributes to human diseases such as the spread of cancer to other sites and lymphademas (localized fluid retention and tissue swelling), little is known about the molecules that regulate the formation of new lymphatic vessels, a process known as lymphangiogenesis.”
“However, a team of researchers, led by Sophia Tsai and Ming-Jer Tsai, at Baylor College of Medicine, Houston, has now identified a role for the gene regulatory protein COUP-TFII in lymphangiogenesis in mouse embryonic development and tumor lymphangiogenesis in adult mice.”
“We also know that Spreds, in contrast, inhibit VEGF-C signaling, which is important in lymphangiogenesis, and that”
“In contrast to Spred1 and Spred2, which regulate developmental lymphangiogenesis, Sprouty2 and Sprouty4 are important negative regulators of developmental angiogenesis in vivo.”
“Therefore, drawing an analogy from the different functions of Sproutys and Spreds in Xenopus tropicalis, we propose that Sproutys inhibit PLC-γ / PKC-dependent VEGF-A signaling and angiogenesis, while Spreds inhibit Ras-dependent VEGF-C signaling and lymphangiogenesis.”
“Not only did Judah Folkman single-handedly create the research discipline of angiogenesis, he also played a very fundamental role in the extension of the same principles to the field of lymphangiogenesis research," says Stanley G. Rockson, MD, Editor-in-Chief of the Journal and Chair of the Scientific Advisory Board of the Lymphatic Research Foundation.”
“Since the degree of tumor lymphangiogenesis and vascularization may theoretically be related to the risk of lymph node metastasis, we sought to evaluate the relationship between lymph vessel invasion (LVI), lymphatic microvascular density (LVD), microvascular density (MVD) and VEGF-A expression, with SLN status and other known adverse clinical risk factors.”
“Kobayashi N, Harada M, Takeoka M, Kawai Y, et al. (2008) Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment.”
“These data suggest that, in contrast to Spred1 and Spred2, which are important negative regulators of developmental lymphangiogenesis rather than developmental angiogenesis, as previously reported”
“We showed that Sproutys are negative regulators for angiogenesis rather than lymphangiogenesis in vivo.”
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