“The findings may lead to a way to treat hydrocephalus using medication that prevents this fat molecule, called lysophosphatidic acid LPA, from binding to cells.”
“Using a single strain of human mammary epithelial cells, we found that a wide variety of agonists, such as lysophosphatidic acid (LPA), uridine triphosphate, growth hormone, vascular endothelial growth factor, insulin-like growth factor-1 (IGF-1), and tumor, require EGFR activity to induce ERK phosphorylation.”
“Autotaxin (ATX) is an extracellular lysophospholipase D that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC).”
“There is also a tumor-marker test that measures levels of plasma lysophosphatidic acid (LPA) being developed.”
“Lafleur J, Mwaikambo BR, Zhu T, Gagnon C, et al. (2009) The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration.”
“Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, et al. (2008) Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells.”
“Lpathomab is a monoclonal antibody that binds to the bioactive lipid lysophosphatidic acid”
“MBOAT2 also prefers oleoyl-CoA, using lysophosphatidic acid and lysophosphatidylethanolamine as acyl acceptors.”
“* AZX100 also significantly decreased expression of CTGF and collagen caused by endothelin and lysophosphatidic acid”
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