mAb

There may be a fairly small percentage of patients that benefit from mAb therapy — cancer patients with specific cancers sometimes, only those whose biopsy reveal that are “lucky” with respect to CD20, certain auto-immune disease patients, and certain transplant patients.

The Volokh Conspiracy » “Fannie Mae Health Care”: 2009

Following the project's completion, Hengrui will retain the intellectual property rights of the mAb and any patents related to the mAb's development.

unknown title 2011

The indication and market potential for the first mAb is very broad.

unknown title 2011

ChemPartner will head pre-clinical research activities, including target protein preparation and assay system establishment, generation and optimization of lead antibodies, as well as pharmacokinetic and preformulation studies, while Hengrui will lead drug development for the mAb.

unknown title 2011

This diagonal force on the lever is equivalent to that given spontaneously by the stimulatory anti-CD3 mAb.

Biosingularity Snowcrash 2010

+DDCs showed lower allostimulatory property than LCs, a process that was partly reversed by anti-PD-L1 mAb.

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"Our findings with mAbs demonstrate that TCR activation function depends on the angle at which anti-CD3 mAb binding takes place," says the study's lead author, Sun Taek Kim, PhD, of Dana-Farber and Harvard.

Biosingularity Snowcrash 2010

Moreover, anti-PD-L1 mAb increased the production of IFN -

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By adjusting the angle of the laser beams, researchers could subtly alter the strength and direction with which the TCR and mAb or TCR and pMHC were brought together.

Biosingularity Snowcrash 2010

The activation occurred only after the mAb or pMHC bound to the TCR was dragged along the T cell surface with optical tweezers.

Biosingularity Snowcrash 2010