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The most obvious case is, that modifications accumulated solely for the good of the young or larva, will, it may safely be concluded, affect the structure of the adult; in the same manner as any malconformation affecting the early embryo, seriously affects the whole organisation of the adult.— On the Origin of Species by Means of Natural Selection or the Preservation of Favoured Races in the Struggle for Life. (2nd edition)
It appears certain that malconformation and lameness in horses, produced by too much work on hard roads, -- that affections of the eyes in this animal probably caused by bad ventilation, -- that tendencies towards many diseases in man, such as gout, caused by the course of life and ultimately producing changes of structure, and that many other diseases produced by unknown agencies, such as goitre, and the idiotcy resulting from it, all become hereditary.— The Foundations of the Origin of Species Two Essays written in 1842 and 1844
This malconformation below did not, however, affect his strength -- it rather added to it; and there were but few men in the ship who would venture a wrestle with the boatswain, who was very appropriately distinguished by the cognomen of Jemmy Ducks.— Snarley-yow or The Dog Fiend
Mr. and Mrs. Bloomfield arrived; the former a benevolent, grey-haired man, with a large nose and small mouth, yet with nothing of the foolish look which often accompanies such a malconformation; and the latter a nice-looking little body, middle-aged, rather more; with half-grey curls, and a cap with black ribbons.— Adela Cathcart, Volume 1
"Personal deformity from malconformation is uncommon; the only instance I remember being that of a young woman, whose utterance was unintelligibly nasal, in consequence of an imperfect development of the palatine bones leaving a gap in the roof of the mouth."— Three Voyages for the Discovery of a Northwest Passage from the Atlantic to the Pacific, and Narrative of an Attempt to Reach the North Pole, Volume 2

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