Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun An exceptionally large dose, as of a drug or vitamin.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A dose of drug or vitamin far exceeding the normal or recommended amount, and usually given intentionally. Compare overdose.
  • verb transitive To dose (a patient) with a very large amount of a drug.
  • verb transitive To dose with a very large amount of (a drug).

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

mega- +‎ dose

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Examples

  • It was at these afternoon conferences that Frei began to introduce the idea of megadose combination chemotherapy with autologous marrow support to the fellows and junior faculty.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • It was at these afternoon conferences that Frei began to introduce the idea of megadose combination chemotherapy with autologous marrow support to the fellows and junior faculty.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • It was at these afternoon conferences that Frei began to introduce the idea of megadose combination chemotherapy with autologous marrow support to the fellows and junior faculty.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • But the point of taking a multivitamin is not to "megadose" but to provide a balanced spectrum of vitamins and minerals.

    Are you taking vitamin pills? Ann Althouse 2009

  • That alone is enough to do the job, but the ever-efficient State follows with a megadose of potassium chloride.

    Miracles, Inc. T.J. Forrester 2011

  • That alone is enough to do the job, but the ever-efficient State follows with a megadose of potassium chloride.

    Miracles, Inc. T.J. Forrester 2011

  • All it takes to prevent that is one megadose of Vitamin A, administered twice a year.

    Writer Unboxed » Blog Archive » AUTHOR INTERVIEW: Marshall Karp, part two 2009

  • The megadose chemotherapy regimen had not produced a hint of benefit, not “even a modest improvement,” as the investigators glumly informed the audience.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Yet the surer Frei became about megadose chemotherapy, the less sure some others around him seemed to get.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • At eight and a half years, nearly 60 percent of patients in the megadose/transplant arm were still alive, versus only 20 percent in the control arm.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

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