from The American Heritage® Dictionary of the English Language, 4th Edition
- adj. Of or relating to monogenesis; monogenetic.
- adj. Relating to monogenism.
- adj. Of or regulated by one gene or one of a pair of allelic genes.
- adj. Producing offspring of only one sex, as some species of aphids.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. of or relating to monogenesis or to monogenism
- adj. regulated by a single gene
- adj. producing offspring of only one sex
- adj. having a single derivative at a point
- n. A derivative of a monogenic function
from the GNU version of the Collaborative International Dictionary of English
- adj. Of or pertaining to monogenesis.
- adj. Producing only one kind of germs, or young; developing only in one way.
from The Century Dictionary and Cyclopedia
- Same as monogenous.
- In chem., combining with an element in only one form; forming only one compound with a monovalent element.
- Same as monogenetic.
- In petrography, noting a fragmental rock, conglomerate or breccia, whose fragments or parts are all of one kind of rock.
- Having a univocal derivative: the better and now accepted form for monogeneous, 2, and monogenous, 3.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- adj. of or relating to an inheritable character that is controlled by a single pair of genes
Prenatal tests for some of these single-gene maladies -- known as monogenic diseases -- are available today, but they require a needle to be inserted into the mother's womb and therefore carry a small risk of miscarriage.
These so-called monogenic conditions — diseases like hemochromatosis (where the body absorbs too much iron) or Huntington's disease — are easy to research, because the associations are pretty much binary.
"Recent advances in genetics such as the identification of the responsible genes for several forms of Maturity Onset Diabetes of the Young (MODY), now referred to as monogenic diabetes, have established precedents linking specific drug therapies to defined subtypes of diabetes patients," said Robert Smith, MD, of Brown University in Providence, R.I. and co-author of the statement.
It's called monogenic diabetes - a very rare form of the disease that's diagnosed in infants.
University of Chicago found she had a rare genetic mutation known as monogenic diabetes.
Although single-gene or "monogenic" diabetes has interested scientists for years, it was often viewed by physicians as a laboratory curiosity.
The company said it is therefore discontinuing development of its SB-509 product in order to focus on its pipeline of ZFP Therapeutics for HIV and monogenic diseases.
He and his co-workers transferred a mutant gene for hypoxanthine phosphoribosyltransferase (HPRT), which is defective in Lesch-Nyhan syndrome, an X-linked monogenic defect of purine metabolism .
The first area to which experimental geneticists turned their attention after the birth of gene targeting in mammals was monogenic diseases.
Cystic fibrosis is one of the most common monogenic disease and was chosen for gene-targeting studies by Smithies and his co-workers [53, 54].
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