Evolutionary design principles of modules that control cellular differentiation: consequences for hysteresis and multistationarity— CiteULike: Everyone's library
Results: To isolate particular design principles, we have computationally evolved random regulatory networks with a preference to result either in hysteresis (switching threshold depending on current state), or in multistationarity (having multiple steady states), two commonly observed dynamical features of GRNs related to differentiation processes.— CiteULike: Everyone's library
We conclude that the structures of real GRNs are consistent with selection to favor one or other of the dynamical features of multistationarity or hysteresis.— CiteULike: Everyone's library
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