from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Proliferation of fibroblastic cells in bone marrow, causing anemia and sometimes enlargement of the spleen and liver.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A myeloproliferative disorder of the bone marrow, in which the marrow undergoes fibrosis.
from the GNU version of the Collaborative International Dictionary of English
- n. Fibrosis of the bone marrow.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. fibrosis of the bone marrow
NEW ORLEANS ― A first-in-its class oral medication provides significant and durable relief for patients with a rare, debilitating and lethal bone marrow disorder called myelofibrosis, researchers at The University of Texas M.
Abstracts already released suggest that the studies are going to point to much bigger potential for '424 beyond its lead indication myelofibrosis, which is already viewed as a blockbuster opportunity.
*** Pharmaceuticals Novartis said an experimental drug for the treatment of myelofibrosis, a rare form of blood cancer, met the goals of a late-stage study, which should pave the way to file the drug for regulatory approval in the second quarter.
An enlarged spleen is one of the characteristics of myelofibrosis.
ZURICH— Novartis AG said Tuesday an experimental drug for the treatment of myelofibrosis, a rare form of blood cancer, met the goals of a late-stage study, which should pave the way to begin filing the drug for regulatory approvals in the second quarter.
The cause of myelofibrosis is unknown, and there are few treatment options.
Novartis, based in Basel, Switzerland, said the study showed treatment with ruxolitinib, also known as INC424, provided a statistically significant reduction in spleen size in patients with different forms of myelofibrosis when compared with the best available therapy.
Incyte Corp.'s Jakafi pill obtained U.S. Food and Drug Administration approval Wednesday, making it the first drug approved specifically for myelofibrosis, a rare bone-marrow disease, according to the government agency.
The bone marrow of people with myelofibrosis is replaced by scar tissue, which can cause an enlarged spleen, anemia, decreased white blood cells and platelets.
Dave Fisher, 69, a founding member and lead singer of the 1960s folk group the Highwaymen, whose recording of the Civil War anti-slavery song "Michael, Row the Boat Ashore" became a surprise pop hit in 1962, died May 7 at his home in Rye, N.Y., of myelofibrosis, a rare blood disease.
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