from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Of or pertaining to the myoepithelium
from the GNU version of the Collaborative International Dictionary of English
- adj. Derived from epithelial cells and destined to become a part of the muscular system; -- applied to structural elements in certain embryonic forms.
- adj. Having the characteristics of both muscle and epithelium.
from The Century Dictionary and Cyclopedia
- Pertaining to or having the characters of myo-epithelium.
She found that extremely low doses of carageenan disrupted the internal cellular architecture of healthy breast tissue, leading her to conclude: "The widely used food additive, carageenan has marked effects on the growth and characteristics of human mammary myoepithelial cells in tissue cultures at concentrations much less than those frequently used in food products to improve solubility."
She concludes: "The association between exposure to low concentrations of carageenan in tissue culture and destruction of mammary myoepithelial cells may be relevant to the occurrence of invasive mammary malignancy in vivo and provides another approach to investigation of mammary carcinoma."
The transformed MCF10AT cells form hyperplastic ductal structures on xenografting that have both myoepithelial and luminal components, suggesting that the MCF10A parental line has properties of a bipotential breast epithelial progenitor
The lack of a relevant basal lamina (BL), defective ECM deposition, and missing stromal or myoepithelial components
Biopsy of the tumour revealed it to be an epithelial-myoepithelial carcinoma of the base of the tongue.
Immunostaining of CD105 in salivary gland tumors imply participation of angiogenesis in the development of malignant lesions, as well as some role for myoepithelial cells in the control of new vessel formation.
Basal-like tumors share expression markers with the underlying basal (myoepithelial) layer of normal breast ducts, are ER negative, exhibit frequent chromosome segmental gains/losses, and are associated with poor outcome in most studies.
Mackay A, Grigoriadis A, Cossu A, Reis-Filho JS, et al. (2004) Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer.
A prevailing view is that breast epithelial stem cells give rise to bipotent basal/luminal progenitors, which then give rise to basal and luminal restricted progenitors, and from there to differentiated basal/myoepithelial and luminal epithelial cells
SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation.
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