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Examples
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Genetic and environmental factors both clearly play a role in narcolepsy-cataplexy.
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The findings of Dr. Mignot's group indicate that narcolepsy-cataplexy is linked to autoimmunity and involves T-cells.
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In people with the HLA variants that predispose to narcolepsy-cataplexy, there is about a 20-fold higher frequency of the disorder if variants in the TCRA gene are present.
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It is yet to be known which people with the genetic variants will go on to develop narcolepsy-cataplexy.
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HLA variations, however, do not fully account for narcolepsy-cataplexy.
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Instead it identifies groups that are more likely to show narcolepsy-cataplexy and groups that are less likely to show the disorder.
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Genetic and environmental factors both clearly play a role in narcolepsy-cataplexy.
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HLA variations, however, do not fully account for narcolepsy-cataplexy.
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For example, further studies to characterize the T cells in people with narcolepsy-cataplexy could help reveal whether specific environmental factors - such as infections - contribute to the disorder.
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For example, further studies to characterize the T cells in people with narcolepsy-cataplexy could help reveal whether specific environmental factors - such as infections - contribute to the disorder.
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