“NF1 is caused by mutations in a gene called neurofibromin, or Nf1, which makes a protein with the same name.”
“In additional experiments, Brown showed that reduced levels of neurofibromin affected a different biochemical pathway in brain nerve cells than in peripheral nerve cells.”
“In brain nerve cells, reduced neurofibromin leads to less of a molecule known as cyclic AMP.”
“Because these mice have one defective copy of the NF1 gene, similar to children with neurofibromatosis 1, the cells make fewer copies of the gene's protein, neurofibromin.”
“Her results showed that, unlike peripheral nerve cells, retinal ganglion neurons with less neurofibromin had shorter branches and died more often when stressed.”
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