from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A white poisonous glycoside, C29H44O12,extracted from the seeds of the African trees Strophanthus gratus and Acokanthera ouabaio, that is used as a heart stimulant and by some African peoples as a dart poison.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. g-strophanthin, a poisonous cardiac glycoside.
from The Century Dictionary and Cyclopedia
- n. A glucoside which exists in the root and wood of ouabaio (wabaio), Acokanthera ouabaio, from which is prepared the arrow-poison of the Somalis of the east coast of Africa.
The active principle is a chemical called ouabain, and it is a powerful stimulant of the muscles of the heart.
Ph.D. thesis research on the effects of experimental congestive heart failure, asphyxia and ouabain on high energy phosphates and creatine content of the guinea pig heart.
In moderate dosage ouabain is used today to treat emergency heart failure; in excessive doses it makes the heart go crazy, pumping wildly until it collapses.
Myers, Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain site of Na+, K+, ATPase, Science 208 1980: 503-5; Kennedy, A.
Acokanthera shrub, which has bark filled with "ouabain", closely-related to a source of arrow poison famously used to kill elephants.
Such mastication appears to liberate the ouabain from the bark and mix it with saliva to form a coarse colloid, which is then specifically applied only to the lateral line hairs.
"It's been known for a long time that injecting the sodium/potassium pump inhibitor ouabain into the brain can induce seizures in rats," says Clapcote, and it's also known that mice lacking two of three forms of the pump - either the "alpha1" or "alpha2" forms - are free from seizures.
Action of ouabain on submaxillary secretion in the dog
Figure 5C, the application of 0.1 mM ouabain for 1 min substantially reduces the massive postplateau hyperpolarizations in membrane-tethered δ-ACTX-Hv1a-expressing lLN
The continued increase in ouabain effect following washout is likely due to slow tissue diffusion of the hydrophobic drug.
Wordnik is becoming a not-for-profit! Read our announcement here.