pancytopenia

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“
Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers.

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Definitions (2)

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  1. noun See aplastic anemia.

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Examples (12)

  • In our present zebrafish studies, however, a pancytopenia phenotype was observed in TERT-knockdown embryos following MO injections, which was rescued by following injection of a zTERT mutant (ΔTR-zTERT) lacking the TR domain, suggesting that the cytopenia is not due to direct inhibition of authentic telomerase activity itself. —  PLoS ONE Alerts: New Articles
  • Upon zTERT knockdown, zebrafish embryos show reduced telomerase activity and are viable, but develop pancytopenia resulting from aberrant hematopoiesis. —  PLoS ONE Alerts: New Articles
  • We show that zTERT knockdown causes hypochromic anemia at the onset of circulation, and that this is accompanied by the impaired differentiation of blood cells and their eventual apoptotic cell death leading to a severe reduction of hematopoietic cells ( 'pancytopenia'), during embryogenesis. —  PLoS ONE Alerts: New Articles
  • Taken together, these results suggest that TERT is involved in both definitive and primitive hematopoietic waves, which may therefore be responsible for the subsequent pancytopenia in TERT deficient zebrafish embryos. —  PLoS ONE Alerts: New Articles
  • A deficiency in TERT in zebrafish causes ineffective hematopoiesis accompanied by anemia, impaired specification and differentiation, hematopoietic cell apoptosis, and pancytopenia. —  PLoS ONE Alerts: New Articles
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