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- n. An analog of calcitriol (the active form of vitamin D) that is used for the prevention and treatment of secondary hyperparathyroidism
Sorry, no etymologies found.
ADVANCE studied 360 patients with SHPT and detectable CAC who were randomised to open label treatment with cinacalcet (30-180 mg/day) plus low-dose vitamin D (less than or equal to 2 ug IV paricalcitol equivalent/dialysis session) or to flexible vitamin D therapy.
Thus, paricalcitol appears to attenuate CsA-induced nephropathy by suppression of inflammatory, pro-fibrotic, and apoptotic factors through inhibition of the nuclear factor-κB, Smad, and mitogen-activated protein kinase signaling pathways.
In addition, paricalcitol decreased the number of TUNEL-positive nuclei and reduced the expression of pro-apoptotic markers in CsA-treated HK-2 cells.
Using an in vitro model, we treated HK-2 cells with CsA and found that paricalcitol attenuated the CsA-induced increases in phosphorylated extracellular signal-regulated and c-Jun
Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet). chronic kidney disease, which is associated with low vitamin D levels.
Either way, he said there are drugs that can lower them, including Fontus Pharmaceuticals Inc's Rocaltrol, also called calcitriol; Genzyme Corp's Hectorol (doxercalciferol); Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet).
Genzyme Corp's Hectorol (doxercalciferol); Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet).
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