“Its goal -- the resurrection of an old antibiotic called paromomycin -- may sound modest.”
“There is no reliable treatment for cryptosporidium enteritis - certain agents such as paromomycin, atovaquone, nitazoxanide, and azithromycin are sometimes used but they usually have only temporary effects.”
“The communities that most need paromomycin still lack health systems that can deploy it, so experts are scrambling to devise a treatment program that relief workers can manage independently.”
“Would paromomycin work as a first-line therapy in India?”
“Their new company -- the grandly named Institute for OneWorld Health -- secured $5 million in seed money from the Gates Foundation in 2002, and by 2003 the stage was set for a full-dress paromomycin study.”
“The to-do list was daunting -- form a company, organize a large clinical trial, push paromomycin through the approval process and find a way to manufacture it -- but things happened fast.”
“The paromomycin initiative was seeded five years ago by an American scientist named Victoria Hale, but the crisis it addresses dates back to 1976.”
“If all goes as planned, paromomycin will soon be available for $10 a cure -- just one twentieth of what treatment now costs in Bihar.”
“Hale's team is now using the results to get paromomycin approved as a remedy for kala azar, and the Gates Foundation is outfitting an Indian firm to produce large quantities at low cost.”
“Hale had heard about MSF's experience with paromomycin, and she was mesmerized by Sundar's talk.”
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