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“Therefore, a composition, and methods thereof, that modulates and inhibits IL-10 activity can alter the development and sustainment of autoimmune disease and related symptoms and ameliorate or reduce pathogen-associated immunopathology.”
“The sensitivity to LPS most likely relates to the presence of CD14/TLR2/TLR4 receptors on the fibroblast surface, which further indicate that fibroblast serve an important sentinel function through pathogen-associated molecular pattern (PAMP) recognition”
“Recognition of pathogen-associated molecular patterns by pattern recognition receptors”
“Davis, California, United States of America Recognition of pathogen-associated molecular patterns by pattern recognition receptors (PRRs) activates the innate immune response.”
“The innate immune response relies on recognition of pathogen-associated or microbe-associated molecular patterns (PAMPs or MAMPs) via a set of defined receptors known as pattern recognition receptors (PRRs)”
“TLR family recognises pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediates the production of cytokines necessary for the development of effective immunity.”
“These receptors recognize both pathogen-associated molecular patterns and molecules that are released from damaged tissue.”
“Plants usually recognize pathogen-associated molecular patterns (PAMPs) in the form of chitin, glucan fragments or pathogen recognition receptor (PRR) proteins.”
“Innate immunity presents the first line of defense against infections through the recognition of pathogen-associated molecular patterns.”
“This supports an emerging role for these protein domains to coordinate the cell's response to pathogen-associated RNA.”
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