pentameric

Turns out that it's not the chocolate candy per se that has anticancer properties: The Lombardi Comprehensive Cancer Center at Georgetown University finds that it's an ingredient in cocoa, from which chocolate is made, called pentameric procyanidin.

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Found in cocoa, pentameric procyandin turns off proteins that likely spur the out-of-control division of cancer cells.

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PLN exists in an inhibitory monomeric form and as a less inhibitory or inactive pentameric form

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

WT PLN, and the finding in this study that PLN RΔ14 is not recovered by COP I mediated retrograde transport and has becomes localized at the plasma membrane offers a mechanism by which the concentration of PLN is reduced in the ER and a possible explanation for the destabilisation of the pentameric form of PLN.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Previously, it was demonstrated that PLN RΔ14 mutation causes superinhibition of SERCA2a and that the mutation causes disruption in the stability of its pentameric form

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

The normal pentamer to monomer ratio is 10: 1 and it has been determined that mutations that destabilise the pentamer increase the active monomer concentration inhibiting SERCA2a by altering the dissociation constant between the monomeric and pentameric forms of PLN causing inhibition by mass action

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

A feature of exported proteins is a pentameric motif (RxLxE/Q/D) that is a substrate for an unknown protease.

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Interestingly, FocA has a pore (black circle) in the centre of its pentameric assembly and an axial passage

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Monk R, Taylor AL, Ozbek S, Fascetti N, et al. (2003) Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

This dimer can serve as the core for the formation of pentameric and hexameric oligomers with a ring-like organization.

PLoS ONE Alerts: New Articles 2008