- n. A xanthine derivative used to treat vascular dementia and intermittent claudication resulting from obstructed arteries in the limbs.
- n. a drug (trade name Trental) used to treat claudication; believed to increase the flexibility of red blood cells so they can flow through the blood vessels to the legs and feet
“A meta-analysis analyzed the effect of pentoxifylline on walking distance in 6 randomized and double - or assessor-blinded trials that together studied a total of 600 patients with Fontaine stage II peripheral arterial obstructive disease.”
“Keywords: meta-analysis, pentoxifylline, walking distance Girolami B, Bernardi E, Prins MH et al. Treatment of intermittent claudication with physical training, smoking cessation, pentoxifylline, or nafronyl.”
“In 4 of 6 studies, pain-free walking distance was greater in those treated with pentoxifylline than in control subjects.”
“In these 6 trials, pentoxifylline was found to increase mean pain-free walking distance by 21 m and mean total walking distance by 44 m.”
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