from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An environmentally induced, nonhereditary variation in an organism, closely resembling a genetically determined trait.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A variation in an organism that resembles a genetic one, but has an environmental rather than a genetic cause, and is not inherited
- v. To copy a genetic variation through environmental manipulation
This is called a phenocopy, where an environmental factor induces an effect similar to a genetic mutation.
The beer analogy is wonderful for explaining phenocopy mutation.
The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's disease (FAD) mutations within sporadic AD.
Thus prolonged incubation with HC-056456 produces a phenocopy of the lack-of-hyperactivation phenotype of the CatSper null sperm.
In addition to the pharmacological-phenocopy approach used here for study of the roles of CatSper in activation and hyperactivation of motility, we recently applied a chemical-genetic approach to extend our knowledge of the roles of PKA in the these processes.
In this and other respects, HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm.
We also show that in wild type cells manipulations of sulfur metabolic flux phenocopy the enhanced growth rate of cells with more mtDNA.
Consequently, we then examined if adding exogenous sulfur metabolites to wild type cells would phenocopy the enhanced growth rate seen in cells over-expressing Abf2p.
Analysis of individual pairs of sister kinetochores confirmed that depletion of condensin appears to phenocopy (
Wordnik is becoming a not-for-profit! Read our announcement here.