from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A glycolytic enzyme that catalyzes the phosphorylation of fructose phosphate.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a group of kinase enzymes that convert fructose phosphates to biphosphates
Fructose bypasses the enzyme phosphofructokinase, which is the rate-limiting enzyme in the glucose metabolism pathway.
Now, the enzyme that does this conversion to fructose-1,6-bisphosphate is called phosphofructokinase and it is highly and exquisitely regulated by multiple inputs, including other co-factors as well as other modifications.
He was having trouble with irreproducible results with phosphofructokinase testing for an E~P mechanism by preincubating the enzyme with ATP32 and chasing it with a mixture of F-6-P and unlabeled ATP.
Xu-5-P is generated from glucose metabolism in the hexose monophosphate pathway, which activates phosphofructokinase and promotes the transcription carbohydrate-responsive element-binding protein (ChREBP), thereby increasing the enzymes of lipogenesis, the hexose monophosphate shunt, and glycolysis, all of which are required for lipogenesis.
(ADP-ribose) polymerase phosphofructokinase, liver, B-type 18 124615 2 13 3 19 291 6.69E-045 ±
Adaptive phosphofructokinase aldolase adipose tissue
6.78E-05 74.67E-04 1.01 ± ± 1.95 - 133 3 2 88 1 9 112 1.26 XP_622094. 1 PREDICTED: NP_031441. 2 poly PFKL isoform 1 family, member 1 PARP1 phosphogluconate dehydrogenase NP_032852. 2 phosphofructokinase, liver, B-type (ADP-ribose) polymerase 79782 14 1 18 4 615 3.43E-0513 ± -
"In [the hypothalamus and the liver] the rate of glucose is slowed by the early regulated steps in the glycolytic pathway, most notably by [the enzyme] phosphofructokinase
Wordnik is becoming a not-for-profit! Read our announcement here.