from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The toxin 5-hydroxy-2-methyl-1,4-naphthoquinone.
from the GNU version of the Collaborative International Dictionary of English
- n. A crystalline substance said to be found in the root of a certain plant of the Leadwort (Plumbago) family.
from The Century Dictionary and Cyclopedia
- n. A name given by Dulong to ophioxylin, through an error in identifying the plant from which he obtained the compound.
It includes a non-nitrogenous principle, plumbagin, existing in the form of orange-yellow needles, bitter, acrid, volatile, neutral, slightly soluble in cold water, more soluble in ether, alcohol and hot water.
However, it was completely prevented when plumbagin was added to the medium and this was attributed to prevention of antibiotic resistance.
The LDso of plumbagin is approximately 10 mg / kg body weight (oral and IP) in mice and a 50\% alcoholic extract of the root or whole plant has an LD50 of 500 mg / kg body weight when given IP. 26 In view of the documented abortifacient activity, it should be avoided at all stages of pregnancy.
Furthermore, plumbagin treatment prevented the accumulation of cholesterol and triglycerides in the liver and aorta and caused regression of atheromatous plaques of the thoracic and abdominal aorta.
Studies have shown that plumbagin, when administered orally at a dose of 4 mg / kg body weight, caused tumour regression in rats with 3-methyl-4dimethyl aminoazobenzene (3MeDAB) - induced hepatoma.
Antioxidant activity: At a concentration of 1 mM, plumbagin prevented peroxidation in liver and heart homogenates.
The animals treated with plumbagin excreted more faecal cholesterol and phospholipids.
Immunomodulatory activity: The effect of plumbagin was studied on peritoneal macro phages of BALB / c mice, evaluated by bactericidal activity, hydrogen peroxide production and superoxide anion release.
Hypolipidaemic activity: When administered to hyperlipidaemic rabbits, plumbagin reduced serum cholesterol and
Eye drops containing 50 llg / ml of plumbagin demonstrated significant antibacterial, antiviral and antichlamydial effects in eye diseases with few side effects.
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