from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A toxin obtained from the rhizomes of some South American plants that is the base of the anticancer drug etoposide.
from The Century Dictionary and Cyclopedia
- n. A bitter crystalline substance, C15H14O6 + 2H2O, found in the root of the May-apple, Podophyllum peltatum. It melts at 117° C. or, when anhydrous, at 157° C.: used as a purgative.
Sorry, no etymologies found.
Part 1: Isolation and characterization of deoxy-podophyllotoxin.
In agreement with our results, Stoilov et al. also found that compounds identified via HTS with a minigene reporter construct in HEK 293 cells were capable of specifically enhancing inclusion of exon 10 in endogenous transcripts of The most potent small molecules identified by our DMD exon skipping screen were podophyllotoxin tubulin modulators, and HDAC inhibitors TSA and scriptaid.
The researchers studied the effect of location, plant nutrient concentration, and phytoavailable nutrients in soil on podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States.
Previous research demonstrated that American mayapple leaves contain podophyllotoxin, making way for the development of American mayapple as a high-value crop for American growers.
According to Zheljazkov; "The objective of this study was to estimate podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States and to identify high podophyllotoxin types that could be used for further selection and cultivar development."
This groundbreaking study confirmed that mayapple colonies in the eastern part of the United States can be used for the development of high podophyllotoxin cultivars, which could subsequently provide the base for commercial production of podophyllotoxin in the United States.
Currently, podophyllotoxin is produced commercially using the roots and rhizomes of Indian mayapple, an endangered species harvested from the wild in India, Pakistan, Nepal, and China.
Podophyllyum emodi, produces podophyllotoxin, a compound used in manufacturing etoposide, the active ingredient in a drug used for treating lung and testicular cancer.
"We hypothesized that there might be great variation with respect to podophyllotoxin content within American mayapple across the eastern United States."
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