American Heritage® Dictionary of the English Language, Fourth Edition
- n. Any of a group of organic compounds, such as spermine and spermidine, composed of only carbon, nitrogen, and hydrogen and containing two or more amino groups.
- From poly- + amine (Wiktionary)
“The organic compound spermidine is a polyamine and is found in all living cells.”
“Synthesis and biological evaluation of polyamine toxins as tools for studies of ionotropic glutamate receptors.”
“Polyamines are associated with cell growth and cancer development, and previous research has shown that a polyamine-inhibiting regimen of difluoromethylornithine (DFMO) plus sulindac”
“Researchers found that patients with the highest dietary polyamine intake were more likely to have colorectal adenomas greater than 1 cm and advanced adenomas, compared to those with the lowest dietary polyamine intake”
“They conclude that control of dietary intake of polyamines may be an effective adjunctive strategy to polyamine inhibitors for preventing colorectal adenomas and cancer”
“However, they found that DFMO/sulindac treatment only reduced adenoma risk among patients with lower intake of dietary polyamines, and not among those with higher dietary polyamine intake.”
“Hence, iNOS may down-regulate proline and polyamine production in M1 MØ by competing with Arg II for L-Arg.”
“Li H, Meininger CJ, Hawker JR Jr, Haynes TE, Kepka-Lenhart D, et al. (2001) Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.”
“Presentation Title: Novel oligoamine / polyamine analogues inhibit lysine-specific demethylase 1 (LSD1), induce re-expression of epigenetically silenced genes, and inhibit the growth of established human tumors in vivo”
“LAD2 (A, C) and primary human MCs (B, D) were cultured in polyamine-free medium and sensitized overnight with human myeloma IgE.”
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