Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein (or one of a larger group) whose function is to modify gene expression via changes to chromatin

Etymologies

Sorry, no etymologies found.

Examples

  • Through a series of experiments, the team worked backward from this observation to show that a group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    dailyindia.com News Feed

  • A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    innovations-report

  • The mechanism by which 'polycomb' proteins critical for embyronic stem cell function and fate are targeted to DNA has been identified by UCL scientists.

    PhysOrg.com - latest science and technology news stories

  • Furthermore, profiling data of genes coding for chromatin regulators of homeobox genes, including components of polycomb repressor complex 2 (PRC2), indicated lacking expression of EZH2 in LOUCY and exclusive expression of

    BioMed Central - Latest articles

  • Moreover, targets of the polycomb repressor complex in breast cancer and embryonic stem cells were more methylated in luminal B tumours than in other tumours.

    BioMed Central - Latest articles

  • Discovering that polycomb also binds to these RNAs shows how polycomb might be recruited to genes, which are then repressed to maintain the identities of different cell types.

    PhysOrg.com - latest science and technology news stories

  • However, although polycomb proteins repress genes, they are actually in

    PhysOrg.com - latest science and technology news stories

  • PRC2 (polycomb repressive complex-2) is present in all multicellular organisms and has been shown to be important in stem cell differentiation and early embryonic development.

    PhysOrg.com - latest science and technology news stories

  • The silencing effect of polycomb proteins has been linked to altered chromatin environment and Pol II stalling and, recently, it was proposed that a steric hindrance excluding Pol II elongation may mediate polycomb silencing

    PLoS ONE Alerts: New Articles

  • Hox proteins are important developmental regulators that are controlled by tri-thorax group proteins, such as MLL (mixed lymphocyte leukemia), and by polycomb proteins

    PLoS ONE Alerts: New Articles

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