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Definitions
Wiktionary
- n. biochemistry A protein (or one of a larger group) whose function is to modify gene expression via changes to chromatin
Examples
“Through a series of experiments, the team worked backward from this observation to show that a group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,”
“A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,”
“The mechanism by which 'polycomb' proteins critical for embyronic stem cell function and fate are targeted to DNA has been identified by UCL scientists.”
“Furthermore, profiling data of genes coding for chromatin regulators of homeobox genes, including components of polycomb repressor complex 2 (PRC2), indicated lacking expression of EZH2 in LOUCY and exclusive expression of”
“Moreover, targets of the polycomb repressor complex in breast cancer and embryonic stem cells were more methylated in luminal B tumours than in other tumours.”
“Discovering that polycomb also binds to these RNAs shows how polycomb might be recruited to genes, which are then repressed to maintain the identities of different cell types.”
“However, although polycomb proteins repress genes, they are actually in”
“PRC2 (polycomb repressive complex-2) is present in all multicellular organisms and has been shown to be important in stem cell differentiation and early embryonic development.”
“The silencing effect of polycomb proteins has been linked to altered chromatin environment and Pol II stalling and, recently, it was proposed that a steric hindrance excluding Pol II elongation may mediate polycomb silencing”
“Hox proteins are important developmental regulators that are controlled by tri-thorax group proteins, such as MLL (mixed lymphocyte leukemia), and by polycomb proteins”
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