Definitions

from The Century Dictionary and Cyclopedia

  • Of an earlier stage of development than the gastrula-stage.

Etymologies

Sorry, no etymologies found.

Examples

  • The highly resolved sea urchin pregastrular endomesoderm-gene regulatory network (EM-GRN) provides a unique framework to study the global regulatory interactions underlying endomesoderm induction.

    PLoS Biology: New Articles

  • To determine whether the Pmar1-responsive EM-GRN resolved by the above experiments accurately describes the GRN response to ActivinB signaling in vegetal blastomeres during normal sea urchin development, we characterized the requirement for ALK4 / 5 / 7-ActivinB function in pregastrular endomesoderm specification.

    PLoS Biology: New Articles

  • Identifying this signal and its GRN properties will be necessary to achieve a comprehensive understanding of pregastrular development in echinoderm embryos.

    PLoS Biology: New Articles

  • We report that normal pregastrular endomesoderm specification requires activation of the Pmar1-inducible subset of the EM-GRN by the same cytokine, strongly suggesting that early micromere-mediated endomesoderm specification, which regulates timely gastrulation in the sea urchin embryo, is also ActivinB dependent.

    PLoS Biology: New Articles

  • Interestingly, the GRN response to ActivinB-ALK4 / 5 / 7 signaling in normal pregastrular endomesoderm development is almost identical to that of ectopic Pmar1-driven induction.

    PLoS Biology: New Articles

  • Thus, the primary cellular targets of ActivinB signaling during pregastrular endomesoderm development are the more vegetal (veg2) macromere derivatives.

    PLoS Biology: New Articles

  • A third, unknown Pmar1-mediated signal clears SoxB1 (black line leading to factor circled with solid black line) from endomesoderm precursors and, contrary to previous models of pregastrular endomesoderm development, is independent of micromere-mediated specification of these blastomeres.

    PLoS Biology: New Articles

  • Recent models of pregastrular development in echinoderm embryos have proposed that a single micromere signal specifies veg2 macromere progeny as endo16-expressing endomesoderm progenitors and also causes the gradual clearance of the β-catenin antagonist, SoxB1, from nuclei of these blastomeres [

    PLoS Biology: New Articles

  • These findings provided the initial experimental leverage for constructing the overall sea urchin pregastrular EM-GRN [

    PLoS Biology: New Articles

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