Definitions
American Heritage® Dictionary of the English Language, Fourth Edition
- n. An inactive precursor of a drug, converted into its active form in the body by normal metabolic processes.
Wiktionary
- n. pharmacology A drug that is administered in an inactive form that is metabolised in the body into a biologically active compound.
Etymologies
- pro- + drug (Wiktionary)
Examples
“It belongs to the class of drugs called prodrug - an inactive compound that is converted into an active drug by the body's metabolic processes.”
“Like many cancer drugs, sunitinib is a "prodrug" that requires the CYP450 family of enzymes in the liver to activate the drug for it to be effective.”
“Nektar is developing NKTR-102, a novel prodrug which is a PEGylated form of irinotecan.”
“The company also has other advanced drug delivery technologies including Cobalamin (TM) - mediated targeted delivery and oral drug delivery, its proprietary nanopolymer delivery technology based on the natural vitamin B12 uptake mechanism; Angiolix (R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; Prodrax (R), a non-toxic prodrug which is activated in the hypoxic zones of solid tumors to kill cancer cells;”
“The company also has other advanced drug delivery technologies including Cobalamin-mediated targeted delivery and oral drug delivery, its proprietary nanopolymer delivery technology based on the natural vitamin B12 uptake mechanism; Angiolix, a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; Prodrax, a non-toxic prodrug which is activated in the hypoxic zones of solid tumors to kill cancer cells; Alchemix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance.”
“Because fosphenytoin is a prodrug and is converted to phenytoin after administration, any concern regarding this association is also applicable to fosphenytoin.”
“They do not appear to have any new drug, new prodrug, new method of analyzing for anything.”
The Volokh Conspiracy » Mayo Collaborative Servs. v. Prometheus Laboratories, Inc.
“They do not appear to have any new drug, new prodrug, new method of analyzing for anything.llQuote”
The Volokh Conspiracy » Mayo Collaborative Servs. v. Prometheus Laboratories, Inc.
“I spoke in the House of Commons on the CBC prodrug programme, "The Drug Culture," televised a few weeks ago, and of its effect on youths by showing the so-called "joys" of taking drugs, without properly indicating the abject tragedies of this practice -- and the nationdestroying dangers of widespread use, as we saw in the tragic episode of the old China after the opium wars.”
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