American Heritage® Dictionary of the English Language, Fourth Edition
- n. A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.
- prosta(te) + cycl(ic) + -in. (American Heritage® Dictionary of the English Language, Fourth Edition)
“Perhaps in the pile of documents lies the answer to the continuing mystery of why just before marketing Vioxx, Merck removed a section from its Merck Manual about prostacyclin that arguably would have made Vioxx appear more risky.”
“It binds harmful substances in the blood, stimulates endothelial cell movement, decreases multiple clotting functions, protects red blood cells, stimulates the synthesis of prostacyclin an important substance involved in arterial relaxation, and increases the half life in the circulation of this prostacyclin.”
“It's little technical, but basically gives good reasons for why basically all women and men should take some form of fish oil: * An increased prostacyclin/thromboxane ratio induced by omega-3 FA can facilitate pregnancy in women with infertility problems by increasing uterine blood flow.”
“The dilatory effect of chocolate under resting conditions can be attributed to improved nitric oxide bioavailability, prostacyclin increase, direct effect of chocolate in smooth muscle cells, or activation of central mechanisms," they write.”
“It was in this department that prostacyclin was discovered and its pharmacology developed.”
“The metabolites of the endoperoxides (the stable prostaglandins, the thromboxanes and prostacyclin) haye been called defense hormones.”
“John Vane has discovered prostacyclin and has carried out detailed analyses of its biological effects and function.”
“In contrast to the prostaglandins as well as thromboxanes and prostacyclin the leukotrienes do primarily not act as defense hormones.”
“The prostaglandins and their related substances, which include the so-called stable prostaglandins as well as thromboxane and prostacyclin, can therefore best be characterized as local tissue hormones.”
“In one of them the cyclic endoperoxides constitute an important branching point from which the stable prostaglandins as well as the more unstable thromboxanes and prostacyclin are formed.”
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