proteasomal

Elimination of disulfide bonds in murine Proinsulin 2, in bovine viral diarrhea virus E2 glycoproteins as well as in Human ABCG2 render these proteins sensitive to proteasomal degradation.

PLoS ONE Alerts: New Articles Virginie Renaud et al. 2010

Isolated PA28-αβ stimulated proteasomal activity on Suc-LLVY-MCA substrate up to five-fold and no activity was observed in controls without 20S proteasome testifying the absence of protease contamination in the PA28-αβ preparation.

PLoS ONE Alerts: New Articles Michele Mishto et al. 2010

PHDs-mediated hydroxylation targets HIF-1α for proteasomal degradation via the ubiquitination-dependent Von Hippel-Lindau (VHL) complex, while FIH-1-mediated hydroxylation leads to the inhibition of HIF-1 transactivation.

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

KRP1 is regulated both transcriptionally and post-translationally through regulation of nuclear localization and through proteasomal degradation

PLoS Biology: New Articles Adrienne H. K. Roeder et al. 2010

The regulation of HIF-1α stability by an oxygen-independent degradation pathway was also reported: the molecular chaperone Heat Shock Protein 90 (HSP90) binds and stabilizes HIF-1α, competing with Receptor of Activated protein Kinase C (RACK1), which mediates prolyl hydroxylase/VHL-independent ubiquitination and proteasomal degradation of HIF-1α

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

VHL which promotes HIF-1α ubiquitination and its subsequent proteasomal degradation

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

By dissecting the molecular mechanism of this process, we found that bcl-2 increases HIF-1α protein stability through the involvement of the molecular chaperone HSP90, which was found to protect HIF-1α from proteasomal degradation, even in VHL-deficient cells

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

A recent report demonstrated that RACK1 protein promotes ubiquitination of HIF-1α induced by the HSP90 inhibitor 17-AAG and its subsequent VHL-independent proteasomal degradation competing with HSP90 for binding to PAS domain of HIF-1α

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

In conclusion, our study establishes a molecular link and highlights the possibility that bcl-2 is a new HIF-1α-binding protein whose multivalent interactions are required for the stabilization of HIF-1α, and that nuclear localization of bcl-2 may have an important role in protecting HIF-1α from ubiquitination and proteasomal degradation that commences in the nucleus.

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

A recent study found that a mouse model of chronically reduced proteasomal activity in the brain showed elevated concentrations of several proteins, some of which had previously been found to alter expression in the brain in Alzheimer's disease

Naturejobs - All Jobs Nicholas A. Bishop 2010