Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of proteasome.

Etymologies

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Examples

  • "Our research findings reveal that Baxá protein levels are normally kept at essentially undetectable levels in healthy cells by the protein degradation machine in cells known as proteasomes," said Dr. Victor Yu, who led the Institute of Molecular and Cell Biology (IMCB) research team.

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  • A human cell contains about 30,000 proteasomes: these barrel-formed structures can break down practically all proteins to 7-9-amino-acid-long peptides.

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • The results showed that cells really break down faulty proteins using the ubiquitin system, and we now know that up to 30% of the newly-synthesised proteins in a cell are broken down via the proteasomes since they do not pass the cell's rigorous quality control.

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • Proteins so labelled are then broken down – degraded – rapidly in cellular "waste disposers" called proteasomes.

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • It is the specificity of the E3 enzyme that determines which proteins in the cell are to be marked for destruction in the proteasomes.

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • The labelled proteins are then fed into the cells '"waste disposers", the so called proteasomes, where they are chopped into small pieces and destroyed.

    Press Release: The Nobel Prize in Chemistry 2004

  • Proteins so labelled are then rapidly broken down – degraded – in cellular "waste disposers" called proteasomes.

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  • Stohwasser R, Giesebrecht J, Kraft R, Muller EC, Hausler KG, et al. (2000) Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-gamma and lipopolysaccharide.

    PLoS ONE Alerts: New Articles

  • Seeger M, Janek K, Jungblut PR, Dahlmann B (2007) Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation.

    PLoS ONE Alerts: New Articles

  • Moreover, when 20S proteasomes were inhibited by MG132 (final concentration of 5 µM) no substrate degradation was observed, confirming the absence of other proteases in the 20S proteasome preparation.

    PLoS ONE Alerts: New Articles

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