protein-protein love

protein-protein

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Etymologies

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Examples

  • Most protein-protein interactions in the cell are not due to random mutation.

    Behe

  • His whole example of (paraphrased) "it's easier to gum up something that functions properly than to develop new protein-protein interactions".

    Behe

  • Which Behe explained in his book where a different class of interactions from host protein-protein interactions.

    Behe

  • "One can view all necessary biological features that are beyond what it's biologically reasonable to expect of unintelligent processes – for example, all cellular protein complexes containing two or more protein-protein binding sites – as just more and more examples of fine-tuning of the universe for life, akin to the unique events that produced the moon".

    Behe

  • Behe makes it very clear in EoE that even the evolution of new protein-protein binding sites (which are required for the creation of molecular machines) is hampered by an asserted requirement for multiple, simultaneous mutations.

    Behe's Test

  • His basic premise is that the evolution of certain very fundamental things in the cell, such as new protein-protein binding sites, requires multiple, simultaneous mutations, which are extemely unlikely to happen by natural means.

    Behe's Test

  • From EoE, page 135: "Generating a single new cellular protein-protein binding site is of the same order of difficulty or worse than the development of chloroquine resistance in the malarial parasite".

    Behe's Test

  • We know that protein-protein interactions evolve in the lab and in nature and that it happens one mutation at a time.

    Behe's Test

  • This is a strawman argument, because the evolution of new protein-protein binding sites does not require any such thing.

    Behe's Test

  • Indeed, he is asserting that it is not possible to build protein complexes because even a single new protein-protein interaction is extremely unlikely to arise.

    Behe's Test

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