Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Alternative spelling of proteasome.

from The Century Dictionary and Cyclopedia

  • n. A sporozoan of the genus Proteosoma.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. a form of vaccine that can be administered by an inhaler

Etymologies

Sorry, no etymologies found.

Examples

  • In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into their proper protein form.

    PhysOrg.com - latest science and technology news stories

  • The cell has its own trash can called the proteosome, and damaged proteins are deposited there.

    Health News from Medical News Today

  • Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.

    Not all "Lact" Words Are the Same

  • Advancement of therapeutics is unfortunately too frequently driven by serendipity; Takeda/Millennium's own successful drug Velcade (bortezomib), a first-in-class proteosome inhibitor, is one example.

    The War on Cancer: A Long and Ongoing Struggle (ALNY, CELG, MRK, NVS, PFE)

  • The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.

    PhysOrg.com - latest science and technology news stories

  • Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, et al. (2002) Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

    PLoS ONE Alerts: New Articles

  • Brunelle et al. found that the different cytotoxic drugs all caused a rapid decrease in MCL-1 protein levels via proteosome-mediated degradation, allowing cell death to proceed quickly.

    EurekAlert! - Breaking News

  • To explore the molecular mechanism by which dh404 disrupts the Keap1-mediated suppression of Nrf2, we examined effect of dh404 on the Keap1-mediated Nrf2 ubiquitination and subsequent proteosome-mediated degradation as well as the assembling of Keap1-Cul3-Rbx1 E3 ligase complex for the Nrf2 ubiquitination and degradation in HEK293 cells as previously described

    PLoS ONE Alerts: New Articles

  • We have demonstrated that Nrf2 protein turnover in cells is very fast and most of Nrf2 proteins are rapidly degraded via the ubiquitin-proteosome system

    PLoS ONE Alerts: New Articles

  • We and others have demonstrated that Keap1 functions as a substrate adaptor protein for a Cul3/Rbx1 E3 ligase complex to target Nrf2 ubiquitination and subsequent proteosome-mediated degradation

    PLoS ONE Alerts: New Articles

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