“In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into their proper protein form.”
“The cell has its own trash can called the proteosome, and damaged proteins are deposited there.”
“Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.”
“Advancement of therapeutics is unfortunately too frequently driven by serendipity; Takeda/Millennium's own successful drug Velcade (bortezomib), a first-in-class proteosome inhibitor, is one example.”
“The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.”
“Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, et al. (2002) Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.”
“Brunelle et al. found that the different cytotoxic drugs all caused a rapid decrease in MCL-1 protein levels via proteosome-mediated degradation, allowing cell death to proceed quickly.”
“To explore the molecular mechanism by which dh404 disrupts the Keap1-mediated suppression of Nrf2, we examined effect of dh404 on the Keap1-mediated Nrf2 ubiquitination and subsequent proteosome-mediated degradation as well as the assembling of Keap1-Cul3-Rbx1 E3 ligase complex for the Nrf2 ubiquitination and degradation in HEK293 cells as previously described”
“We have demonstrated that Nrf2 protein turnover in cells is very fast and most of Nrf2 proteins are rapidly degraded via the ubiquitin-proteosome system”
“We and others have demonstrated that Keap1 functions as a substrate adaptor protein for a Cul3/Rbx1 E3 ligase complex to target Nrf2 ubiquitination and subsequent proteosome-mediated degradation”
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