Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A normal gene that has the potential to become an oncogene.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics A
gene , that promotes thespecialization anddivision of normal cells, that becomes anoncogene followingmutation
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a normal gene that has the potential to become an oncogene
Etymologies
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Examples
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The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung's disease.
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Activation or overexpression of a proto-oncogene see below promotes the transformation of a cell from normal to a cancer cell.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Activation or overexpression of a proto-oncogene see below promotes the transformation of a cell from normal to a cancer cell.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Activation or overexpression of a proto-oncogene see below promotes the transformation of a cell from normal to a cancer cell.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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They had found activated versions of the src proto-oncogene in Rous sarcoma virus.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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They had found activated versions of the src proto-oncogene in Rous sarcoma virus.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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The crucial implication of the Varmus and Bishop experiment was that a precursor of a cancer-causing gene—the “proto-oncogene,” as Bishop and Varmus called it—was a normal cellular gene.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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The crucial implication of the Varmus and Bishop experiment was that a precursor of a cancer-causing gene—the “proto-oncogene,” as Bishop and Varmus called it—was a normal cellular gene.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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In the laboratory, we call this the six-degrees-of-separation-from-cancer rule: you can ask any biological question, no matter how seemingly distant—what makes the heart fail, or why worms age, or even how birds learn songs—and you will end up, in fewer than six genetic steps, connecting with a proto-oncogene or tumor suppressor.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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In the laboratory, we call this the six-degrees-of-separation-from-cancer rule: you can ask any biological question, no matter how seemingly distant—what makes the heart fail, or why worms age, or even how birds learn songs—and you will end up, in fewer than six genetic steps, connecting with a proto-oncogene or tumor suppressor.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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