American Heritage® Dictionary of the English Language, Fourth Edition
- n. A defective segment of DNA that resembles a gene but cannot be transcribed.
“Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee.”
“A bit further down in the human pseudogene is a deletion mutation, where one particular letter is missing.”
“For example, there's what's termed a pseudogene copy of one of the BRCA genes, which has inactivating mutations in it, and no longer produces any protein.”
“Usually, that's it, and that copy becomes a so-called pseudogene, functionless litter, part of the famous junk DNA.”
“In the region between the two gamma genes and a gene that works after birth, human DNA contains a broken gene (called a "pseudogene") that closely resembles a working gene for a beta chain, but has features in its sequence that preclude it from coding successfully for a protein.”
“Thus finding a pseudogene in both chimps and humans that has exactly the same mutations in the same places was compelling evidence for him of common ancestry.”
“In "The Design of Life" they presented a case in which humans and guinea pigs share the same mistake. (page 133) the GULO pseudogene.”
“It doesn't make sense to design a pseudogene (a gene that no longer functions as a gene) once, let alone twice — once in chimpanzees and once in humans.”
“That strong evidence from the pseudogene points well beyond the ancestry of humans.”
“The beginning of the human pseudogene has two particular changes in two nucleotide letters that seems to deactivate the gene.”
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