“Because radiosensitization utilizing curcumin can allow smaller doses of radiation to be theoretically used for treatment, there is a much lesser effect of radiation to the surrounding normal tissues that receive radiation when treating a cancerous target (ultimately there could be less complications to a patient following radiation therapy).”
“Tang W, Desano J, Burstein E, et al. (2008) Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis.”
“We are currently carrying out more detailed mechanism studies to delineate the involvement of Notch signaling pathway in miR-34-induced inhibition of pancreatic CSC and its role in chemo/radiosensitization of pancreatic cancer with p53 loss of function.”
“There are several radiobiological rationales that may explain our observation including radiosensitization by the rose bengal, additive cell kill or augmentation of the host immune response by the interaction of the two modalities.”
“As radiation was applied many weeks after rose bengal dosing, and effects also occurred in new lesions not present when rose bengal was administered, this phenomenon may not arise solely from conventional radiosensitization, "added the authors.”
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