American Heritage® Dictionary of the English Language, Fourth Edition
- n. An enzyme that catalyzes the exchange of short pieces of DNA between two long DNA strands, particularly the exchange of homologous regions between the paired maternal and paternal chromosomes.
“Requiring only fifteen minutes to provide accurate results, the company's proprietary technology, called recombinase polymerase amplification (RPA), comes in a battery powered device the size of a book.”
“The recombinase genes served as guideposts for researchers exploring how the gene mecA had arrived.”
“An ingenious development of gene targeting has been made by introducing recognition sites for the enzyme Cre recombinase, so-called loxP sites, into existing genes.”
“When mice carrying such "floxed" genes are mated with transgenic mice expressing Cre recombinase, the target gene of the offspring is modified through Cre action [42-44].”
“Another site-specific recombinase, Flp, is also frequently used to construct conditional targeting of genes in mice .”
“What this means is that a simple system exists, with both a RAG1-like gene and RSSs, as an independent functional unit: what we would expect for a direct, “reduced” predecessor to the supposedly irreducible VDJ recombinase system.”
“In vivo transposition mediated by VDJ recombinase in human T lymphocytes.”
“VDJ recombinase-mediated transposition of the BCL2 gene to the IGH locus in follicular lymphoma.”
“Even worse for Wells thesis, BCRA2, a key gene in some breast cancers (see above), regulates a key recombinase (which is responsible for chromosomal integrity).”
“When fed a specific synthetic hormone, a DNA recombinase editing enzyme is activated in a specific population of cells lining the lungs.”
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