Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun An enzyme that catalyzes the synthesis of a complementary RNA molecule from an RNA template.
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Eigen says this is too short to encode for an RNA enzyme that might act as a replicase—that is, an enzyme that increases the rate of RNA replication and reduces the mutation rate.
SuperCooperators Martin A. Nowak 2011
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As Eigen (197 l) has shown, a mutant distribution of RNAs replicating without the aid of a replicase cannot integrate sufficient information for the functioning of a higher-level unit utilizing several types of encoded enzymes.
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In fact, this prediction can be confirmed by the isolation of a rudimentary RNA replicase ribozyme (52, 53).
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In fact, this prediction can be confirmed by the isolation of a rudimentary RNA replicase ribozyme (52, 53).
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However, all the advances of ribozymology notwithstanding, the prospects of a bona fide ribozyme replicase remain dim as the ribozymes designed for that purposes are capable, at best, of the addition of ~10 nucleotides to a oligonucleotide primer, at a very slow rate and with fidelity at least an order magnitude below that required for the replication of relatively long RNA molecules [28,29].
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No, the viral genome can be replicated just fine in vitro using the viral replicase.
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The ATP to ADP energy exhange with each step causes a quanta of vibration to move along the 5′-3′ strand which by recoil bumps the replicase to the next nucleotide.
Quantum Hyperion Sean 2008
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There are phonon physics associated with how replicase moves on a DNA strand.
Quantum Hyperion Sean 2008
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This scenario presupposes that among all possible RNA sequences, there exist RNA replicase ribozymes, capable of synthesizing RNA using the information in an RNA template.
Good Math, Bad Math, and David Berlinkski - The Panda's Thumb 2006
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Each of these nine rudimentary polymerases is a potentially promising evolutionary intermediate between ligase and replicase.
Good Math, Bad Math, and David Berlinkski - The Panda's Thumb 2006
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