from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An protein kinase inhibitor derived from the kamala tree (Mallotus philippinensis)
from The Century Dictionary and Cyclopedia
- n. A flesh-colored or yellow crystalline dyestuff, (C11H10O3)3 obtained from Echinus Philippinensis. It is the active constituent of the vermifuge kamila. Also called mallotoxin.
Sorry, no etymologies found.
Anderson noted that a concentrated ethereal solution of kamala after a few days formed a solid crystalline mass, yellow, very soluble in ether; this substance he named _rottlerin_, C_11_H_10_O_3_.
After stimulation with Wnt5a (1 μg/ml, 30 minutes, 1 hour, 2 hours), Gö 6976 (100 nM, 30 minutes), and/or rottlerin (1 μM), EPC was lysed with lysis buffer (Cell Signaling) containing
Wnt5a (1 μg/ml) or PKC delta inhibitor, rottlerin (1 μM) were used. * indicates p doi: 10.1371/journal. pone.0005765.g003
Importantly, increased cardiac marker gene expression by Wnt5a was also inhibited by rottlerin, suggesting that PKC delta is an important mediator for cardiac gene expression via non-canonical Wnt signaling.
For the inhibitory assay, rottlerin (1 μM, Calbiochem), PKC epsilon translocation inhibitor peptide and its control peptide (both 25 μM, Calbiochem), or Gö6976
The PKC delta inhibitor rottlerin significantly blocked co-culture-induced cardiac differentiation in vitro, whereas inhibitors directed against the classical Ca
Incubation with the relatively selective PKC delta inhibitor, rottlerin (1 μM), significantly attenuated cardiac differentiation (
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